Dextran coated magnetic cross-linked iron oxide nanoparticles (CLIO) have superparamagnetic Fe3O4 iron oxide core (8-10 nm in diameter) imbedded within the matrix of dextran sugar strands of 40 or 70 kDa in size. Dextran strands are cross-linked to prevent their disassociation, ensuring long-term stability during storage and in biological fluids, such as blood. Due to the dextran sugar coat CLIO particles are highly biocompatible and have a long blood half life, making them optimal for both in vitro and in vivo applications. 

 

CLIO nanoparticles are available with a variety of surface chemistries that can be used for bioconjugation of biological ligands for a range of biomedical applications:​

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• Loading antibodies and other biomolecues through Biotin-Streptavidin interaction or EDC/NHS chemical reaction.​​

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• Fluorescently labeled CLIO nanoparticles can be used as dual magnetic and fluorescence imaging and MRI probes.

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• CLIO nanoparticles can be used to target specific cells and tissues in vivo, or for development of in vitro bioassays.

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• Dual fluorescence-magnetic probes for cell separation, flow cytometry, fluorescence associated cell sorting (FACS)​.

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More detailed information on nanoparticle functionalization can be found here. Please contact us if you do not see a specific surface chemistry needed for your application. We are always willing to work with our customers to develop new surface functionalizations.

 

Magnetic CLIO Nanoparticle Products